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Reasons for failed IVF – what is worth knowing before the procedure?

According to statistics for 2019, the success rate for IVF at the Lada clinic was 48.39%.  This is a high rate.  Why can’t a 100% guarantee be achieved?  This is due to the large number of factors that can make IVF ineffective.

Why egg fertilization does not occur during IVF: common factors

IVF program consists of several stages:

  1. Comprehensive survey of the pair.
  2. Controlled ovarian stimulation of the ovaries (or observation in the natural cycle).
  3. Follicle puncture, oocyte collection.
  4. ICSI fertilization and embryo culture.
  5. Transfer of the embryo to the uterine cavity.
  6. Laboratory confirmation of pregnancy.

Successful IVF requires all of its stages to be successful.  Moreover, each can be complicated by a number of factors.  Let’s consider them in order.

Partner Compatibility

Already at the planning stage of pregnancy, problems may be revealed.  With the existence of many antigenic coincidences in parents, they speak of immunological incompatibility.  In this case, pregnancy either does not occur at all, or spontaneously terminates due to rejection of the fetus.

Age of partners

The period from 20 to 35 years old is considered optimal for pregnancy. In men over 35-40 years old, the number of motile spermatozoa with the correct morphology gradually decreases. However, the most important thing is the woman’s age, since every year not only the ovarian reserve decreases, but the quality of oocytes also deteriorates.

Quality of reproductive material

The viability of embryos directly depends on the indicators of germ cells. This is one of the main reasons why embryos die during IVF. The low quality of eggs or sperm, in turn, may be the result of severe and chronic diseases, not only of a reproductive nature. Bad habits, an unhealthy lifestyle, stress: physical and psychological also have a negative impact.

Genetic anomalies

Chromosomal problems are rare. But the risk of genetic pathologies is dangerous not only with the death of embryos, but also with the likelihood of reproductive loss of pregnancy or the birth of a sick child.

Hormonal disorders

One of the causes of infertility is hormonal imbalance, leading to serious health changes. In preparation for the IVF protocol, a thorough screening of the hormonal profile is carried out to individually select the ovarian stimulation protocol and increase the chances of pregnancy.

Problems of hemostasis

Blood clotting disorders can occur as pregnancy progresses. If the patient’s hemostasis was initially increased, the risk of microthrombus formation in the placenta and uterine vessels increases.

Fallopian tube affections

In chronic inflammatory processes, hydrosalpinx forms in the pelvic organs. These are accumulations of fluid in the fallopian tubes, the toxic effect of which destroys the embryos.

Other disorders of the organ also have a negative effect. In lesions of the fallopian tubes, 2 outcomes are possible:

  • no implantation in IVF;
  • an ectopic pregnancy occurs.

Endometrial pathology

The inner lining of the uterus is the site of embryo transfer. Successful implantation requires that the mucosa has the correct thickness, structure and microbiome. The endometrium is not always able to create optimal conditions for the survival of the embryo. Causes:

  • endometritis;
  • adhesions and scars on the uterus;
  • hyperplasia;
  • various neoplasms: polyps, fibroids, uterine cysts, etc.

Medical errors

The procedures for collecting reproductive material, laboratory fertilization and direct embryo implantation require high professionalism. One of the most important factors in successful IVF is that the protocol is carried out by a competent specialist. Such doctors work in the Lada clinic. Consultation with a reproductive specialist with high qualifications and extensive experience is the first step towards a healthy pregnancy.

Failed IVF protocol – what’s next?

Lack of conception is not yet an indicator of the presence of problems, especially those that cannot be avoided with the help of modern reproductive technologies. An unsuccessful IVF attempt gives the doctor more information, which can be analyzed to significantly increase the chances of getting pregnant.

How to increase the chances of embryo implantation?

After an unsuccessful protocol, it is necessary to undergo all examinations prescribed by the doctor. The test results will provide the practitioner with important information that will help to adjust the approach in the following protocols.

How to increase the chances of getting IVF from the patient’s side? It is necessary to strictly follow all the instructions of the reproductive specialist and other doctors who are involved in the treatment of infertility. As a rule, the recommendations are as follows:

  • lead a healthy lifestyle;
  • get rid of bad habits;
  • take prescribed medications: medications and vitamins;
  • reduce stress levels.

Modern medicine allows you to bypass almost any reproductive problem.

Danylova Kateryna
Danylova Kateryna
Reproductionist, obstetrician-gynecologist of the first category.

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Клиника репродуктивного здоровья "Лада"
ул. Среднефонтанская, 19В, ЖК «Чудо-город» 65039 Украина, г.Одесса
(0482) 373747, [email protected]