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“Delayed” motherhood. Creation of a personal bank of oocytes

Timely motherhood, sooner or later, is part of the mandatory life plans of every woman! And everyone has their own time. Some patients want to postpone childbirth and delay the implementation of their reproductive function. The reasons are individual… A woman can actively engage in education, career growth in her professional activities. We can hear very weighty arguments: “… until I’m ready to start a family, I have to get on my feet…”, “I haven’t met a life partner…”, “There are no living conditions…” and many others. The number of women postponing motherhood “for later” is growing. But after 35, the likelihood of conceiving and giving birth to a child is rapidly decreasing. This is directly related to the depletion of the ovarian reserve. After 35 years, the quality of oocytes decreases. And the frequency of chromosomal mutations increases in them (these are the longest-living cells of the female body). Inevitability, but true…

Normal ovarian reserve is considered to be

  • the patient’s age is up to 35,
  • FSH level on days 2-3 of the menstrual cycle up to 8 IU/L,
  • AMG level is 1.0-2.5 ng/ml
  • Inhibin B level is 40-100 pg/ml
  • the number of basal follicles <10 mm in diameter on days 2-3 of the menstrual cycle at least 5 in each ovary
  • the volume of the ovary is not less than 8 cube cm

So how do you stop the irreversible passage of time? And how to create this “pause” on the biological clock of a woman? It would seem impossible, BUT! There is a unique technique that allows you to create a cryobank of your own eggs. The reasons for each woman are individual. But they can be divided into two main groups: social (discussed above) and medical. For medical reasons, the creation of a cryobank of your oocytes is carried out for the following reasons:

  • forthcoming chemotherapy and radiation therapy,
  • planned massive surgical interventions on the pelvic organs, endometriosis,
  • impossibility of fertilization of all oocytes or their part in the IVF program (lack of sperm suitable for ICSI; no husband in the clinic on the day of follicle puncture)
  • if vitrification of embryos is not possible for ethical (religious) reasons,
  • if the family history is aggravated by the onset of early menopause (premature, genetically determined ovarian wasting).

Our Clinic uses vitrification to preserve oocytes. The main advantage of the oocyte vitrification method, in comparison with slow cryopreservation, is the ability to freeze oocytes for a long time without losing their viability. This method minimizes the likelihood of cell damage during the freezing process and does not reduce the effectiveness of ART programs. As a result, after thawing of oocytes, embryologists receive up to 99% of viable eggs capable of fertilization, whereas when using the slow freezing technique, no more than 60% of oocytes survive. The cryostorage is equipped with automated equipment that continuously maintains a constant storage temperature. This allows you to keep frozen eggs in perfect condition indefinitely. The creation of a personal bank of oocytes has a number of undeniable advantages. First, it is a unique way of maintaining a woman’s fertility. This method is reliable and in demand. It is a kind of “bioinsurance against childlessness”. Oocyte collection is possible both in the natural menstrual cycle and in a cycle with controlled ovarian stimulation. Eggs have a long shelf life and can be used at any time. And the most important advantage of this technique is the birth of one’s own genetic offspring in the future. An excellent opportunity to postpone motherhood with your own eggs, without resorting to oocyte donation in ART programs when planning pregnancy at a late reproductive age. Delayed motherhood by creating a personal bank of oocytes is by no means propaganda of late birth. Every woman, if she is ready and willing, should realize her maternal plans precisely at reproductive age. BUT, if it is difficult for a number of reasons, we, doctors, are obliged to provide her with a choice and a real opportunity to postpone the implementation of her reproductive function for a more favorable period.

Danilova Ekaterina Alekseevna

Obstetrician-gynecologist of the first category, reproductologist
Medical center for reproductive health Lada
DOCTOR’S PAGE

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Клиника репродуктивного здоровья "Лада"
ул. Среднефонтанская, 19В, ЖК «Чудо-город» 65039 Украина, г.Одесса
(0482) 373747, [email protected]